A gluconolactone PHA-containing regimen including the Exuviance Purifying Cleansing Gel, Soothing Toning Lotion, Multi-Protective Day Fluid SPF15 (morning application) and Evening Restorative Complex (evening application) was assessed on 25 women with sensitive skin and moderate to advanced photoaging. All parameters of photoaging were significantly improved after six and twelve weeks of twice daily use, including firmness, sallowness, fine lines, wrinkles, roughness, hyperpigmentation and pore size (p<0.05). Silicone replicas revealed a reduction in the appearance of fine lines and wrinkles by over 30% in twelve weeks. Significant improvements were also observed in skin dryness and scaling (p<0.05). The products were well tolerated by the sensitive skin panelists and any preexisting irritation was improved during treatment, including erythema, tightness and tingling (p<0.05).

Alternate Exuviance products
Gentle Cleansing Cream, Multi-Protective Day Creme SPF 15, Ultra Restorative Creme. Alternate NeoStrata products: NeoStrata Facial Cleanser, Daytime Protection Cream SPF 15, Ultra Moisturizing Face Cream.

References
Bernstein EF, Green BA, Edison B, Wildnauer RH. Poly Hydroxy Acids (PHAs): Clinical Uses for the Next Generation of Hydroxy Acids. Skin & Aging Sep. 2001 Supplement.

Mean Relative % Improvement
(Compared to Baseline)